GAME GENIE CODES: S.

 Sagaia
 Saint Sword
 Separation Anxiety
 Shadow Blasters
 Shadow Dancer
 Shadowrun
 Shaq Fu
 Shining Force - The Legacy of Great Intention
 Shining Force 2 - Return of the King
 Shining in the Darkness
 Shinobi 3 - Return of the Ninja Master
 Shinomekyu - Labyrinth of Death
 Simpsons, The - Bart's Nightmare (see Bart's Nightmare)
 Simpsons, The - Krusty's Super Funhouse (see Krusty's Super Funhouse)
 Sonic the Hedgehog
 Sonic the Hedgehog 2
 Sonic 3
 Sonic & Knuckles
 Sonic 2 & Knuckles
 Sonic 3 & Knuckles
 Sonic Spinball
 Space Invaders '91
 Spider-Man & the X-men - Arcade's Revenge
 Spider-Man - The Animated Series
 Spider-Man Vs the Kingpin
 Spiderman & Venom - Maximum Carnage (see Maximum Carnage)
 Spiderman and Venom - Separation Anxiety (see Separation Anxiety)
 Splatterhouse 2
 Splatterhouse 3
 Star Control
 Star Flight
 Stargate
 Stimpy's Invention starring Ren & Stimpy
 Stormlord
 Street Fighter 2 - Special Champion Edition
 Streets of Rage
 Streets of Rage 2
 Streets of Rage 3
 Streetsmart
 Strider
 Strider 2
 Sub Terrania
 Super Hang-On
 Super Monoco GP
 Super Monaco GP 2 (see  Ayrton Senna's Super Monaco GP 2)
 Super Street Fighter 2 -The New Challengers
 Super Thunder Blade
 Superman
 Sword of Vermillion
 Sylvester & Tweety in Cagey Capers